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KMID : 0355620170430040272
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2017 Volume.43 No. 4 p.272 ~ p.275
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A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report
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Viviano Massimo
Addamo Alessandra
Cocca Serena
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Abstract
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AbstractBisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavorable course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death.
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KEYWORD
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Bisphosphonate-associated osteonecrosis of the jaw, Sepsis, Necrotizing fasciitis, Jaw fractures
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